P237 Stenotrophomonas maltophilia isolates from cystic fibrosis patients eliminate competitor bacteria

Lung disease represents the primary cause of death in cystic fibrosis (CF) patients and bacterial infections are recognized as major contributors to worsening lung functions. Polymicrobial where more than one pathogen colonizes lungs CF associated with worse outcomes. During these polymicrobial infections, cooperative antagonistic interactions between different bacteria can impact microbial communities affect progression. Stenotrophomonas maltophilia is a broadly distributed emerging that infects approximately 10–40% all patients. Infections difficult treat because S. isolates resistant many antibiotics. infected have higher risk require transplant an increased death. In both environment during must engage other survive. It currently unknown how compete against bacteria. We investigated obtained at medical centers Atlanta, USA, Queensland, Australia. These included from female male pediatric adult clinics. performed co-cultures competitor also whole genome sequencing isolates. observed several displayed potent antibacterial properties, efficiently eliminated will investigate potential mechanisms used by strains eliminate Our results provide evidence Work described here could novel insights for development therapeutics pathogens.